Stanley Manne Childrens Research Institute

THE MISSION OF STANLEY MANNE CHILDREN'S RESEARCH INSTITUTE ("MANNE RESEARCH INSTITUTE") IS TO GENERATE NEW KNOWLEDGE AND TRANSLATE ADVANCEMENTS IN THE PREVENTION, DIAGNOSIS AND TREATMENT OF DISEASES THAT AFFECT CHILDREN'S HEALTH THROUGH ADOLESCENCE AND ADULTHOOD. MANNE RESEARCH INSTITUTE'S MULTIDISCIPLINARY TEAMS ARE COMMITTED TO MAKING DISCOVERIES THAT WILL IMPROVE THE LIVES OF CHILDREN AND THEIR FAMILIES. MANNE RESEARCH INSTITUTE FACULTY MEMBERS INVESTIGATE A RANGE OF CHILDREN'S HEALTH AND DISEASES ACROSS THE TRANSLATIONAL SCIENCE SPECTRUM. MANNE RESEARCH INSTITUTE'S STUDIES ARE LED BY OVER 750 RESEARCHERS AND STAFF AND ARE ORGANIZED INTO FOUR SCIENTIFIC PILLARS: BASIC AND PRECLINICAL SCIENCE, CLINICAL AND COMMUNITY TRIALS; COMMUNITY, POPULATION HEALTH, AND OUTCOMES; AND QUANTITATIVE SCIENCE. RESEARCHERS AND STAFF INCLUDE PHYSICIANS, SCIENTISTS, POSTDOCS, COORDINATORS, STATISTICIANS, DATA ANALYSTS, TRAINEES, AND OTHERS WHO SHARE THEIR EXPERTISE. THE PEDIATRICIANS AND SCIENTISTS ROUTINELY COLLABORATE WITH LURIE CHILDREN'S ACADEMIC PARTNER, NORTHWESTERN UNIVERSITY, AND OTHER MEDICAL CENTERS AND ACADEMIC INSTITUTIONS ACROSS THE GLOBE, AS WELL AS WITH COMMUNITY PARTNERS SUCH AS SCHOOLS AND GOVERNMENTS. MANNE RESEARCH INSTITUTE RECEIVES EXTERNAL FUNDING ANNUALLY FOR RESEARCH FROM THE NATIONAL INSTITUTES OF HEALTH (NIH) AND OTHER FEDERAL AGENCIES. IT IS ONE OF THE NATION'S PREMIER INSTITUTES FOR PEDIATRIC RESEARCH, INVESTING MORE DOLLARS AND RESOURCES IN PEDIATRIC RESEARCH THAN ANY OTHER AREA HOSPITAL. IN ADDITION TO THE CLINICAL AND POPULATION HEALTH RESEARCH FACILITIES, MANNE RESEARCH INSTITUTE HAS APPROXIMATELY 125,000 SQUARE FEET OF STATE-OF-THE-ART LABORATORY SPACE. THE RESEARCH INSTITUTE'S WET-LAB RESEARCH IS LOCATED IN THE LOUIS A. SIMPSON & KIMBERLY K. QUERREY BIOMEDICAL RESEARCH BUILDING ON NORTHWESTERN UNIVERSITY'S CHICAGO CAMPUS. THE BUILDING INCLUDES WET BENCH LABORATORIES, ANIMAL FACILITIES, AND CONFERENCE, EDUCATIONAL, OFFICE, AND COLLABORATIVE SPACE. MANNE RESEARCH INSTITUTE PILLARS BASIC AND PRECLINICAL SCIENCE RESEARCHERS AT MANNE RESEARCH INSTITUTE CONDUCT LABORATORY EXPERIMENTS THAT INVESTIGATE ESSENTIAL FUNCTIONS OF BIOLOGICAL PROCESSES AND THE FUNDAMENTAL MECHANISMS OF DISEASES AND DISORDERS AFFECTING CHILDREN'S HEALTH. BY CLOSING GAPS IN SCIENTIFIC KNOWLEDGE, BASIC AND PRECLINICAL SCIENCE RESEARCHERS PROVIDE THE FOUNDATION TO DEVELOP NEXT-GENERATION TECHNOLOGIES AND TREATMENTS FOR PEDIATRIC PATIENTS. THE BASIC AND PRECLINICAL SCIENCE PILLAR LABORATORY-BASED PROGRAMS ARE ORGANIZED INTO VIRTUAL SCIENTIFIC NEIGHBORHOODS PROMOTING COLLABORATIONS BETWEEN INVESTIGATORS, STAFF, AND TRAINEES. THESE NEIGHBORHOODS INCLUDE: * DEVELOPMENTAL BIOLOGY * ENGINEERED SOLUTIONS FOR HEALTH * FERTILITY AND HORMONE PRESERVATION AND RESTORATION * HOST-MICROBIAL INTERACTIONS, INFLAMMATION, AND IMMUNITY * HUMAN MOLECULAR GENETICS AND PHYSIOLOGY * IMMUNE DEVIATION AND DISEASE * INJURY, REPAIR, AND REGENERATION * MOLECULAR AND TRANSLATIONAL CANCER BIOLOGY * NEUROBIOLOGY * PERINATAL ORIGINS OF DISEASE CLINICAL AND COMMUNITY TRIALS CLINICAL AND COMMUNITY TRIALS RESEARCHERS AT MANNE RESEARCH INSTITUTE TRANSLATE THE MEANINGFUL DISCOVERIES OF BASIC SCIENCE INTO PROMISING CLINICAL APPLICATIONS THROUGH EVALUATION OF NEW DIAGNOSTIC TESTS AND DRUGS, BEHAVIORAL TREATMENTS, AND OTHER INTERVENTIONS TO DETERMINE THEIR EFFECTS ON PEDIATRIC HEALTH. MULTIDISCIPLINARY TEAMS OF RESEARCHERS COLLABORATE TO STUDY COMPLEX CHILDHOOD HEALTH ISSUES IN AREAS SUCH AS CRITICAL CARE, ONCOLOGY, TRANSPLANT MEDICINE, AND NEONATOLOGY. THEIR RESEARCH GENERATES INNOVATION IN THE DIAGNOSES, TREATMENT, AND PREVENTION OF DISEASES AND DISORDERS IN THE PEDIATRIC POPULATION. COMMUNITY, POPULATION HEALTH, AND OUTCOMES COMMUNITY, POPULATION HEALTH, AND OUTCOMES RESEARCHERS AT MANNE RESEARCH INSTITUTE SEEK TO IMPROVE HEALTH, HEALTH CARE DELIVERY, AND ACCESS TO CARE FOR CHILDREN AND YOUTH FROM A BROAD RANGE OF BACKGROUNDS AND ENVIRONMENTS. THESE RESEARCH LEADERS ADVANCE OUR KNOWLEDGE ABOUT THE NATURAL HISTORY, BIOLOGICAL, PSYCHOLOGICAL, SOCIAL, BEHAVIORAL, AND ENVIRONMENTAL CAUSES AND INFLUENCERS OF COMMON AND PROMINENT CHILD HEALTH PROBLEMS. THEIR RESEARCH INFORMS ACTION FOR PATIENTS, FAMILIES, COMMUNITIES, HEALTH SYSTEM LEADERS, AND POLICYMAKERS. MUCH OF THEIR PROGRAM EVALUATION WORK IS CONDUCTED IN PARTNERSHIP WITH COMMUNITY-BASED ORGANIZATIONS AS EVIDENCE IS TRANSLATED INTO CLINICAL AND PUBLIC HEALTH INTERVENTIONS. QUANTITATIVE SCIENCE QUANTITATIVE SCIENCE EXPERTS COLLABORATE WITH RESEARCHERS ACROSS MANNE RESEARCH INSTITUTE TO PROVIDE CUTTING-EDGE STATISTICAL AND ANALYTICAL SUPPORT AND COMPUTATIONAL TECHNIQUES TO MAXIMIZE RESEARCH IMPACT AND IMPROVE THE HEALTH OUTCOMES OF PEDIATRIC PATIENTS. THEIR EXPERTISE IN STATISTICS, BIOINFORMATICS, DATABASE ANALYTICS, APPLIED CLINICAL INFORMATICS, AND PREDICTIVE ANALYTICS ENABLES RESEARCHERS TO TEST HYPOTHESES, ANSWER RESEARCH QUESTIONS, AND PURSUE UNDERSTANDING OF BEHAVIORS ACROSS DIFFERENT POPULATIONS. RESEARCH STRATEGY MISSION-ALIGNED, ENGAGING, IMPACTFUL STRATEGIC AREAS * ADVANCED THERAPEUTICS: END-TO-END DIAGNOSTIC DEVELOPMENT WITH EARLY-STAGE TRIALS FOR CHILDREN AND INDIVIDUALIZED THERAPY. * HEALTH@HOME: INNOVATIVE HEALTHCARE DELIVERY AND TECHNOLOGY SOLUTIONS OUTSIDE TRADITIONAL MODELS. * FERTILITY AND HORMONE PRESERVATION: EARLY LIFE FERTILITY PRESERVATION, BIOLOGY, AND TECHNOLOGY. * PERINATAL ORIGINS OF DISEASE: BASIC, TRANSLATIONAL, CLINICAL PRACTICE AND PUBLIC HEALTH RESEARCH FOR DETERMINANTS OF EARLY LIFE HEALTH TRAJECTORIES. * HEALTHY BRAIN: THE BASIS OF AND APPROACHES TO MENTAL, BEHAVIORAL, AND NEUROLOGICAL HEALTH. * GLOBAL HEALTH COLLABORATION: FOSTER INTERNATIONAL COLLABORATIONS TO ADDRESS GLOBAL HEALTH DISPARITIES.