MILITARY HEALTH RESEARCH FOUNDATION

MEDICAL DEVICE DEVELOPMENT RESEARCH MHRF CONDUCTS MEDICAL DEVICE RESEARCH FOR THE MILITARY PRIMARILY FOCUSED ON DEALING WITH TRAUMA, VASCULAR INJURY, RESUSCITATION AND OTHER COMBAT CARE TREATMENTS WHICH INCLUDE THE FOLLOWING PROJECTS: ENDOVASCULAR PERFUSION AUGMENTATION FOR CRITICAL CARE - MHRF HAS BEEN AWARDED A COOPERATIVE AGREEMENT FOR THE PERSONALIZED AND ADAPTIVE THERAPY FOR RESUSCITATION AFTER TRAUMA. THIS AGREEMENT PROVIDES FOR THE RESEARCH AND DEVELOPMENT OF INNOVATIVE PATIENT-CENTERED TECHNOLOGIES TO MAINTAIN PHYSIOLOGICAL EQUILIBRIUM IN AN EFFORT TO MINIMIZE PREVENTABLE DEATHS FOR CRITICALLY ILL WARFIGHTERS BY EMPLOYING PERSONALIZED, GOAL DIRECTED PRECISION CRITICAL CARE SUPPORT IN WAYS THAT WERE NEVER BEFORE POSSIBLE. VENTRIGHT - MHRF HAS BEEN AWARDED A COOPERATIVE AGREEMENT FOR THE RESEARCH AND DEVELOPMENT OF A PORTABLE VENTILATION MONITORING OPTIMIZING CRITICAL CARE DEVICE FROM THE DEPARTMENT OF DEFENSE IN SUPPORT OF THE AIR FORCE MATERIEL COMMAND. THE OBJECTIVE OF THIS EFFORT IS TO DEVELOP: (A) A BATTERY-OPERATED DEVICE CAPABLE OF COLLECTING AND INTEGRATING VENTILATION AND PHYSIOLOGIC METRICS; (B) DIAGNOSTIC ALGORITHMS CAPABLE OF IDENTIFYING COMMON CRITICAL RESPIRATORY DISEASE STATES AND SUB-OPTIMAL VENTILATION; AND (C) INTEGRATION OF THE DEVICE WITH THE ALGORITHMS TO CREATE A ROBUST AND PORTABLE VENTILATION ANALYTICS MONITOR CAPABLE OF BATTLEFIELD DEPLOYMENT. EVAC - MHRF IS RESEARCHING THE DEVELOPMENT OF THE DESIGN OF A CLINICAL-GRADE EVAC CONTROLLER FOR PROLONGED WEANING TO PROVIDE PARTIAL FLOW WHICH WILL LEAD TO THE DEVELOPMENT OF HARDWARE AND SOFTWARE FOR TEST FIXTURES NEEDED FOR THE EVAC CONTROLLER MANUFACTURING, VERIFICATION AND VALIDATION TESTING AS WELL AS MANUFACTURING OF STERILE UNITS IN FINAL PACKAGING FOR THE VERIFICATION AND VALIDATION AND COMPLETION OF REGULATORY DOCUMENTATION FOR THE EVAC CONTROLLER.PACCMAN - MHRF WILL DEVELOP AND REFINE A PLATFORM OF AUTONOMOUS CRITICAL CARE TERMED PRECISION AUTOMATED CRITICAL CARE MANAGEMENT (PACC-MAN). THE OBJECTIVE OF THE SOFTWARE AND HARDWARE PLATFORM IS TO DELIVER FLUIDS, DRUGS, AND BLOOD PRODUCTS BASED ON PHYSIOLOGIC DATA STREAMS, UTILIZING BOTH RULE-BASED AND MACHINE LEARNING (ML)-BASED ADAPTIVE ALGORITHMS TO OPTIMIZE RESUSCITATION EFFORTS, MINIMIZE PERIODS OF HYPO/HYPERTENSION, AND OPTIMIZE RESOURCES.ORTHO STIM - MHRF IS RESEARCHING HOW TO ACCELERATE BONE STRESS FRACTURES (CUMULATIVE MICRO- TRAUMA INJURIES) AND TRAUMATIC (ACUTE) FRACTURE HEALING WITH THE AIM OF SHORTENING THE TIME TO FULL ACTIVE DUTY USING NONINVASIVE BIOELECTRICAL STIMULATIONS. THE OVERALL PROJECT REQUIRES A TWO-LEVEL RESEARCH STRATEGY 1) IN VITRO STUDIES IN SMALL SEGMENT BONE TISSUE TO DETERMINE THE OPTIMAL BES FREQUENCY SIGNALS TO ACCELERATE BONE FORMATION WHILE DETECTING CHANGE IN MULTIPLE BONE FIXATION MARKERS (PRESENT IN BONE CELLS AND BONE TISSUE) TO ASSESS PROGRESS. 2) SMALL-MEDIUM ANIMAL STUDIES TO TEST THESE IN VITRO FREQUENCIES THAT INDUCE PROTEIN CHANGES AND MINERALIZATION IN BONE VIA APPROPRIATE TISSUE SAMPLING/HISTOPATHOLOGY