CHILDREN'S RESEARCH INSTITUTE

CENTER FOR NEUROSCIENCE RESEARCH (CNR) - SEE SCHEDULE O.PROGRAM SERVICE ACTIVITY 1CENTER FOR NEUROSCIENCE RESEARCH (CNR): THE CNR HAS GROWN RAPIDLY IN THE PAST 10 YEARS WITH SIGNIFICANT INCREASES IN THE PROGRAM AND THE GENERATION OF IMPORTANT SCIENTIFIC DISCOVERIES. THE CNR CURRENTLY COMPRISES 50 FACULTY MEMBERS WITH FULL APPOINTMENTS AT OUR ACADEMIC AFFILIATE, THE GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES (GW). IN RECOGNITION OF THESE ACCOMPLISHMENTS, CNMC CONSTRUCTED A NEW FLOOR OF LABORATORY SPACE IN 2008 TO SERVE AS HOME FOR THE CNR AND TO PROVIDE ADDITIONAL SPACE FOR RECRUITMENTS. THE CNR CURRENTLY RESIDES IN OVER 12,000 SQUARE FEET OF OPEN ARCHITECTURE RESEARCH SPACE. WE BELIEVE THAT THE CNR IS NOW UNIQUELY POISED TO ACCOMPLISH ITS MISSION, AS ITS RESEARCH PROGRAM, RESEARCH LABS, AND SUPPORTING INFRASTRUCTURES ARE NOW PHYSICALLY LOCATED ON THE 6TH FLOOR OF THE MAIN BUILDING OF CNMC. THIS ALLOWS CLOSE INTERACTIONS BETWEEN BASIC NEUROSCIENTISTS, TRANSLATIONAL NEUROSCIENTISTS, AND CLINICIAN NEUROSCIENTISTS, INCLUDING CHILD NEUROLOGISTS, NEONATOLOGISTS, AND CRITICAL CARE PEDIATRICIANS. THIS UNIQUE AND EXCITING SETTING HAS SUPPORTED AND PROMOTED A LARGE NUMBER OF RESEARCH PROJECTS THAT SPAN BASIC, TRANSLATIONAL AND CLINICAL RESEARCH IN NEURODEVELOPMENTAL DISORDERS. THE CNR INCLUDES EIGHT MAJOR AREAS OF RESEARCH, INCLUDING NEURAL STEM CELLS AND DEVELOPMENTAL NEUROBIOLOGY, BRAIN INJURY AND BRAIN PROTECTION, PERINATAL HYPOXIA AND HYPEROXIA, EPILEPSY, NEURO-ONCOLOGY, NEUROFIBROMATOSIS, ATTENTION DEFICIT HYPERACTIVITY DISORDER, AND AUTISM. THE CNR COMPRISES AN EXPANDING GROUP OF HIGHLY PRODUCTIVE LAB-BASED DEVELOPMENTAL NEUROSCIENTISTS, ALL OF WHOM HAVE ESTABLISHED STRONG RESEARCH PROGRAMS AND COLLABORATIONS IN THE AREA OF NEURODEVELOPMENTAL DISORDERS. WHILE THESE INVESTIGATORS HAVE DISTINCT EXPERTISE AND RESEARCH PROGRAMS, THEIR RESEARCH AS A WHOLE IS FOCUSED ON CHILDHOOD NEUROLOGICAL DISORDERS, FROM EARLY STAGES OF WHEN THE NERVOUS SYSTEM IS FIRST ESTABLISHED, TO POSTNATAL STAGES THAT INCLUDE THE FORMATION OF NEURONAL CONNECTIONS AND THE WRAPPING OF NEURONAL PROCESSES BY THE MYELIN INSULATOR. THUS, INVESTIGATORS AT THE CNR HAVE A COMMON GOAL FOR WHICH THEY ARE ALL STRIVING. THE CENTER FOR NEUROSCIENCE RESEARCH HAD $28,607,487 IN EXPENSES FY 2024.

CENTER FOR TRANSLATIONAL SCIENCE - SEE SCHEDULE O.PROGRAM SERVICE ACTIVITY 2CENTER FOR TRANSLATIONAL SCIENCE: THE CENTER FOR TRANSLATIONAL SCIENCE SUPPORTS THE FULL SPECTRUM OF INVESTIGATORS (FACULTY, TRAINEES, AND STAFF) AT CHILDREN'S NATIONAL WHO ARE PERFORMING PATIENT-CENTERED CLINICAL AND TRANSLATIONAL RESEARCH (CTR), AND HEALTH SERVICES RESEARCH (HSR). THE POOL OF SUCH INVESTIGATORS AT CHILDREN'S IS LARGE AND GROWING, AND THESE INDIVIDUALS APPROACH THEIR WORK WITH A WIDE RANGE OF EXPERIENCE, EXPERTISE, AND SUPPORT. IT HOUSES BOTH LARGE PROGRAMS OF EXTRAMURALLY FUNDED RESEARCH (E.G. THE CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) FUNDED BY NIH, THE HRSA-FUNDED PEDIATRIC EMERGENCY CARE AND APPLIED RESEARCH NETWORK/PECARN) AND FACULTY WITH LIMITED FUNDING WORKING ON SPECIFIC, LIMITED PROJECTS. THIS GROWING CENTER EXPENSED $26,367,716 IN FY 2024.