CACNA1A Foundation

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Financial Vulnerability Assessment (Tuckman-Chang)

4 risk indicators measuring financial stability and operational resilience

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Financial Trends

Organization Details

Formation Year

2020

Legal Domicile

Principal Officer

Sunitha Malepati

Phone

2039696552

Tax Period

2024-01-01 to 2024-12-31

CACNA1A Foundation, founded in 2020, is a small nonprofit in the Diseases & Disorders sector that reported $466K in total revenue in fiscal year 2024. Revenue surged 21% from the prior year, signaling strong growth momentum. Expenses of $540K exceeded revenue, resulting in a 16% operating deficit.

Mission

To find specific treatment options and a cure for CACNA1A patients. (See Schedule O for full mission)

Program Service Accomplishments

Program 1

Expenses: $247,475

In 2024, the CACNA1A Foundation launched a 10-year Clinical Assessments Research Study to establish baseline measurements for clinical trials and advance treatment development. We funded multiple...

In 2024, the CACNA1A Foundation launched a 10-year Clinical Assessments Research Study to establish baseline measurements for clinical trials and advance treatment development. We funded multiple research projects, including novel gene therapy strategies, small molecule screening, and antibody validation, while also expanding our Research Network with new working groups. Additionally, our team published a key paper outlining a pathway to clinical trials for CACNA1A-related epilepsies.

Program 2

Expenses: $159,643 Revenue: $15,000

On July 18, 2024, the CACNA1A Foundation hosted its third annual Research Roundtable, bringing together 50 researchers, clinicians, industry representatives, and NINDS grant managers to advance...

On July 18, 2024, the CACNA1A Foundation hosted its third annual Research Roundtable, bringing together 50 researchers, clinicians, industry representatives, and NINDS grant managers to advance clinical trials for CACNA1A-related disorders. We also held our second hybrid Creating Connections Community Conference, uniting over 200 participants, including families and experts, to share research updates and support. This event remains a vital space for connection, education, and empowerment in the rare disease community.

Program 3

Expenses: $34,603

The CACNA1A Foundation raised awareness by participating in national and international events, including Global Genes, the American Epilepsy Society, and Rare Disease Day at the Broad Institute. We hosted 22 virtual meetups for families and launched the Cure Club to boost research participation through personalized outreach. Additionally, we advocated for a unique ICD-10 code for CACNA1A-related neurodevelopmental disorders at the ICD-10 Coordination and Maintenance Committee Meeting.

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Trantor Score

Financial Health Score (300–850) · Liquidity · Solvency · Sustainability · Efficiency

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Liquidity (40%) • Solvency (30%) • Sustainability (20%) • Efficiency (10%)

Financial Overview (2024)

Revenue Breakdown

Contributions & Grants $413,016

Program Service Revenue $15,000

Investment Income $8,897

Other Revenue $28,701

TOTAL REVENUE $465,614

Expense Breakdown

Grants Paid $91,155

Salaries & Benefits $0

Fundraising Expenses $78,327

Program Expenses $441,721

Other Expenses $449,002

TOTAL EXPENSES $540,157

Year-over-Year Comparison

	2024	2023	Change
Revenue	$465,614	$385,860	+0.2%
Expenses	$540,157	$453,703	+0.2%
Net Income	$-74,543	$-67,843	+0.1%

Key Indicators

✓ Grants to Organizations ✗ Grants to Individuals ✗ Lobbying ✗ Political Activity ✗ Foreign Activities ✗ Donor Advised Fund ✓ Schedule B Required

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Financial Health Indicators

Comprehensive financial analysis: Altman Z-Score, liquidity, solvency, sustainability, efficiency, and growth metrics

Financial Distress Indicator

Liquidity & Cash Position

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Altman Z-Score • Liquidity Ratios • Solvency Analysis • Growth Indicators • Efficiency Metrics

Governance

Voting Members

Independent Members

Employees

N/A

Volunteers

Governance Policies

✗ Conflict of Interest Policy

✗ Whistleblower Policy

✗ Document Retention Policy

Special Practices & Reported Activities

✗ Operated a School

✗ Operated a Hospital

✗ Provided First Class Travel

✗ Reported Conflict of Interest

✗ Reported Asset Diversion

✗ Excess Benefit Transaction

✗ Made Political Expenditures

✗ Engaged in Lobbying

✗ Operated Donor Advised Fund

✗ Maintained Art Collections

✗ Filed Form 720

Compensation of Officers, Directors & Key Employees

Total Officers

Total Directors

Key Employees

Highest Compensated

reported

Name	Title	Hours/Week	Role	Reportable Comp	Other Comp	Total
Allison Buchner	Director	5.00	Director	$0	$0	$0
Hala Mirza	Director	2.00	Director	$0	$0	$0
Sarah Greathouse	Director	5.00	Director	$0	$0	$0
Deborah Ondrasik MD	Director	5.00	Director	$0	$0	$0
Michael Strupp	Director	5.00	Director	$0	$0	$0
Lisa Manaster	President	40.00	Officer Director	$0	$0	$0
Sunitha Malepati	Vice President & Treasurer	40.00	Officer Director	$0	$0	$0
Amy Junge	Secretary	10.00	Officer Director	$0	$0	$0

Note: Compensation data is self-reported by the organization on their Form 990. "Reportable Comp" includes salary, bonuses, and other reportable compensation from the organization and related organizations. "Other Comp" includes benefits, deferred compensation, and non-taxable benefits.

Historical Data

Year	Revenue	Expenses	Assets	Net Income
2025	No data	No data	No data	No data
2024	$465,614	$540,157	$726,400	$-74,543
2023	$385,860	$453,703	$863,328	$-67,843
2022	$343,299	$403,405	$876,537	$-60,106
2021	$484,663	$168,599	$488,082	$316,064