INSTITUTE FOR SYSTEMS BIOLOGY

EIN: 912003593 501(c)(3) Science & Technology

RENTON, WA

Total Revenue
$43,611,326
Total Expenses
$46,752,331
Total Assets
$121,196,657
Net Assets
$62,630,122
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Financial Vulnerability Assessment (Tuckman-Chang)

4 risk indicators measuring financial stability and operational resilience

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Financial Trends

Organization Details

Formation Year
1999
Legal Domicile
WA
Principal Officer
JAMES R HEATH PHD
Phone
2067321200
Tax Period
2023-01-01 to 2023-12-31

INSTITUTE FOR SYSTEMS BIOLOGY, founded in 1999, is a mid-sized nonprofit in the Science & Technology sector that reported $43.6M in total revenue in fiscal year 2023. Revenue grew 18% year-over-year, indicating healthy expansion.

Mission

USING THE SCIENCE OF SYSTEMS BIOLOGY TO PREDICT, PREVENT AND CURE DISEASE.

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Trantor Score

Financial Health Score (300–850) · Liquidity · Solvency · Sustainability · Efficiency

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Liquidity (40%) • Solvency (30%) • Sustainability (20%) • Efficiency (10%)

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Financial Overview (2023)

Revenue Breakdown

Contributions & Grants $40,929,618
Program Service Revenue $805,238
Investment Income $1,495,258
Other Revenue $381,212
TOTAL REVENUE $43,611,326

Expense Breakdown

Grants Paid $0
Salaries & Benefits $24,193,843
Fundraising Expenses $478,423
Program Expenses $33,689,837
Other Expenses $22,558,488
TOTAL EXPENSES $46,752,331

Year-over-Year Comparison

2023 2022 Change
Revenue $43,611,326 $37,072,888 +0.2%
Expenses $46,752,331 $41,968,785 +0.1%
Net Income $-3,141,005 $-4,895,897 -0.4%
Key Indicators
✗ Grants to Organizations ✗ Grants to Individuals ✗ Lobbying ✗ Political Activity ✗ Foreign Activities ✗ Donor Advised Fund ✓ Schedule B Required
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Financial Health Indicators

Comprehensive financial analysis: Altman Z-Score, liquidity, solvency, sustainability, efficiency, and growth metrics

Financial Distress Indicator

Liquidity & Cash Position

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Altman Z-Score • Liquidity Ratios • Solvency Analysis • Growth Indicators • Efficiency Metrics

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Governance

Voting Members
15
Independent Members
11
Employees
214
Volunteers
34

Governance Policies

✓ Conflict of Interest Policy
✓ Whistleblower Policy
✓ Document Retention Policy

Special Practices & Reported Activities

✗ Operated a School
✗ Operated a Hospital
✗ Provided First Class Travel
✗ Reported Conflict of Interest
✗ Reported Asset Diversion
✗ Excess Benefit Transaction
✗ Made Political Expenditures
✗ Engaged in Lobbying
✗ Operated Donor Advised Fund
✗ Maintained Art Collections
✗ Filed Form 720

Compensation of Officers, Directors & Key Employees

Total Officers
4
$1,297,536
Total Directors
16
$8,035,180
Key Employees
0
$0
Highest Compensated
5
reported
Name Title Hours/Week Role Reportable Comp Other Comp Total
WASIF RASHEED DIRECTOR 0.50
Director
$0 $260,778 $3,133,967
ARI ROBICSEK MD DIRECTOR 0.50
Director
$0 $224,154 $2,234,673
AMY COMPTON-PHILLIPS MD DIRECTOR 0.50
Director
$0 $0 $2,017,976
LEROY HOOD MD PHD DIRECTOR 0.50
Director
$0 $2,213 $648,564
BRIAN V TURNER DIRECTOR 0.50
Director
$0 $0 $0
CHARLES WATTS MD BOARD CHAIR 1.00
Officer Director
$0 $0 $0
CRAIG MUNDIE DIRECTOR 0.50
Director
$0 $0 $0
DANIEL T LING DIRECTOR 0.50
Director
$0 $0 $0
DAVID SABEY DIRECTOR 0.50
Director
$0 $0 $0
DOUGLAS HOWE DIRECTOR 0.50
Director
$0 $0 $0
HEATHER REDMAN DIRECTOR 0.50
Director
$0 $0 $0
MELANIE L MAYER PHD DIRECTOR (PART YEAR) 0.50
Director
$0 $0 $0
NANCY ALLBRITTON MD PHD DIRECTOR 0.50
Director
$0 $0 $0
ROGER PERLMUTTER MD PHD DIRECTOR 0.50
Director
$0 $0 $0
STEPHEN M GRAHAM DIRECTOR - THRU 6/23 0.50
Director
$0 $0 $0
THOMAS J CABLE DIRECTOR 0.50
Director
$0 $0 $0
JAMES R HEATH PHD PRESIDENT/PROFESSOR 55.00
Officer
$461,454 $57,871 $519,325
NITIN BALIGA PHD SVP DIR OF INTEGRATIVE SCIENCE/PROF 55.00
Officer
$344,533 $63,175 $407,708
KATHY SCANLAN COO/TREASURER 55.00
Officer
$317,474 $53,029 $370,503
ANDREW MAGIS DIRECTOR OF DATA SCIENCE 50.00
Highest
$293,494 $42,588 $336,082
ILYA SHMULEVICH PHD PROFESSOR 50.00
Highest
$250,011 $64,003 $314,014
ROBERT L MORTIZ PHD PROFESSOR 50.00
Highest
$272,937 $38,548 $311,485
SUI HUANG MD PHD PROFESSOR 50.00
Highest
$237,660 $45,974 $283,634
ERIC DEUTSCH PRINCIPAL SCIENTIST 50.00
Highest
$188,819 $43,748 $232,567
Note: Compensation data is self-reported by the organization on their Form 990. "Reportable Comp" includes salary, bonuses, and other reportable compensation from the organization and related organizations. "Other Comp" includes benefits, deferred compensation, and non-taxable benefits.

Historical Data

Year Revenue Expenses Assets Net Income
2024 No data No data No data No data
2023 $43,611,326 $46,752,331 $121,196,657 $-3,141,005
2022 $37,072,888 $41,968,785 $126,586,860 $-4,895,897
2021 $43,313,392 $38,933,529 $81,550,518 $4,379,863
2020 $39,847,320 $40,513,307 $80,193,323 $-665,987
2019 $36,230,866 $41,016,030 $73,280,105 $-4,785,164
2018 $31,249,334 $33,125,028 $74,178,732 $-1,875,694
2018 $31,249,334 $33,125,028 $74,178,732 $-1,875,694
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