Active Site Research Inc

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Financial Vulnerability Assessment (Tuckman-Chang)

4 risk indicators measuring financial stability and operational resilience

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Financial Trends

Organization Details

Formation Year

2023

Legal Domicile

Principal Officer

Joe Torres

Phone

6174175428

Tax Period

2024-06-01 to 2025-05-31

Active Site Research Inc, founded in 2023, is a community nonprofit in the Medical Research sector that reported $2.3M in total revenue in fiscal year 2024. Revenue surged 164% from the prior year, signaling strong growth momentum. The organization ran a surplus of $1.2M, a strong 53% operating margin.

Mission

To eliminate the risks posed by pandemic threats through the advancement of science and innovation in medical countermeasure development, ensuring the health and well-being of individuals and communities worldwide.

Program Service Accomplishments

Program 1

Expenses: $330,152

The Synthetic Innate Immunity program aims to develop medicines that serve as society's first line of defense against emerging viral outbreaks by taking inspiration from natural mechanisms of innate immunity. By encoding natural or engineered pattern recognition receptors PRRs and interferon-stimulated genes ISGs in DNA delivered to the respiratory tract, the program works to persistently enhance a patient's natural sense-and-respond capacity, potentially providing prophylactic protection against a broad range of respiratory viruses for months.

Program 2

Expenses: $235,675

PAN-2025-001 is a single-site, two-arm, parallel-group superiority randomized controlled trial (RCT) with 1:1 allocation, designed to evaluate whether large language model (LLM) use improves the...

PAN-2025-001 is a single-site, two-arm, parallel-group superiority randomized controlled trial (RCT) with 1:1 allocation, designed to evaluate whether large language model (LLM) use improves the ability of novice lab participants to independently perform complex biological tasks. Participants attempt a fixed sequence of five laboratory obstacles that represent the core skills required to create a virus via reverse genetics with or without LLM assistance.

Program 3

Expenses: $222,703 Revenue: $37,893

The organization periodically provides subject-matter expertise in molecular biology and related life sciences disciplines to AI companies. Such services include responding to technical inquiries and developing advanced scientific problem sets designed to evaluate complex biological reasoning and analytical capabilities in emerging AI technologies. These activities further the organizations scientific research mission and promote the responsible development and evaluation of AI tools.

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Trantor Score

Financial Health Score (300–850) · Liquidity · Solvency · Sustainability · Efficiency

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Liquidity (40%) • Solvency (30%) • Sustainability (20%) • Efficiency (10%)

Financial Overview (2024)

Revenue Breakdown

Contributions & Grants $2,215,714

Program Service Revenue $37,893

Investment Income $0

Other Revenue $5,241

TOTAL REVENUE $2,258,848

Expense Breakdown

Grants Paid $0

Salaries & Benefits $301,142

Fundraising Expenses $21,129

Program Expenses $810,587

Other Expenses $752,078

TOTAL EXPENSES $1,053,220

Year-over-Year Comparison

	2024	2023	Change
Revenue	$2,258,848	$854,335	+1.6%
Expenses	$1,053,220	$745,059	+0.4%
Net Income	$1,205,628	$109,276	+10.0%

Key Indicators

✗ Grants to Organizations ✗ Grants to Individuals ✗ Lobbying ✗ Political Activity ✗ Foreign Activities ✗ Donor Advised Fund ✓ Schedule B Required

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Financial Health Indicators

Comprehensive financial analysis: Altman Z-Score, liquidity, solvency, sustainability, efficiency, and growth metrics

Financial Distress Indicator

Liquidity & Cash Position

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Altman Z-Score • Liquidity Ratios • Solvency Analysis • Growth Indicators • Efficiency Metrics

Governance

Voting Members

Independent Members

Employees

Volunteers

N/A

Governance Policies

✗ Conflict of Interest Policy

✗ Whistleblower Policy

✗ Document Retention Policy

Special Practices & Reported Activities

✗ Operated a School

✗ Operated a Hospital

✗ Provided First Class Travel

✗ Reported Conflict of Interest

✗ Reported Asset Diversion

✗ Excess Benefit Transaction

✗ Made Political Expenditures

✗ Engaged in Lobbying

✗ Operated Donor Advised Fund

✗ Maintained Art Collections

✗ Filed Form 720

Compensation of Officers, Directors & Key Employees

Total Officers

$236,451

Total Directors

$83,495

Key Employees

Highest Compensated

reported

Name	Title	Hours/Week	Role	Reportable Comp	Other Comp	Total
Brian Wang VP thru 3-2025	Vice President	40.00	Officer Director	$74,776	$8,719	$83,495
Alexander Kleinman beg 3-2025	Treasurer	40.00	Officer	$69,802	$8,154	$77,956
Joe Torres beg 3-2025	President	40.00	Officer	$75,000	$0	$75,000
William Bradshaw	Secretary	0.50	Officer Director	$0	$0	$0
Jacob Swett	Director	0.50	Director	$0	$0	$0
Ales Flidr	Chairman	0.50	Officer Director	$0	$0	$0

Note: Compensation data is self-reported by the organization on their Form 990. "Reportable Comp" includes salary, bonuses, and other reportable compensation from the organization and related organizations. "Other Comp" includes benefits, deferred compensation, and non-taxable benefits.

Historical Data

Year	Revenue	Expenses	Assets	Net Income
2025	$2,258,848	$1,053,220	$1,352,366	$1,205,628
2024	$854,335	$745,059	$126,827	$109,276